Universitatea "Alexandru Ioan Cuza" Iași - Facultatea de Biologie

 

BIOINFORMATICĂ APLICATĂ
ÎN CERCETAREA BIOMEDICALĂ

Studii universitare de master - Genetică moleculară

   

APLICAȚII BIOINFORMATICE UTILIZATE
ÎN CERCETAREA BIOMEDICALĂ

Studii universitare de master - Laborator Medical
Studii universitare de master - Biotehnologii microbiene și celulare

Materiale pentru Curs & Lucrări practice   Bioinformatics & Molecular Biology Resources
 

◦ PERL: Date, Opratori și Instructiuni (diagramă sintetică) [↓]
◦ CODUL GENETIC: standardul de notare IUBMB/IUPAC: [↓]

Date: intrări/ieșiri: instrucțiunile: print, say: [↓] printf [↓]
◦ Declararea variabilelor: $scalar [↓] @array [↓] %hash [↓]
◦ Declararea constantelor: $scalar, @array, %hash [↓]
Operatori: atrib., aritmetică, egalitate, logică: [↓] ternar [↓]
Șiruri: funcții pentru șiruri [↓], comparații [↓],
Șiruri: codul ASCII [↓], funcția sort: sortare [↓]
Blocuri funcționale: definirea blocurilor {...} [↓] , variabile globale vs. varariabile locale: my [↓] our [↓] local [↓] state [↓]
◦ Blocuri funcționale: subrutine (functii, proceduri): [↓],[↓]
◦ Instrucțiuni de decizie: if, unless, elsif, else [↓]
◦ Instrucțiuni iterative: do, while, until, for, foreach [↓]
◦ Instrucțiuni de control al fluxului în interiorul iterațiilor: next, redo, last, die, exit: [↓], continue: [↓],[↓]
Fișiere: citire, scriere: [↓],[↓]  record separators: [↓]
Referințe: \$scalar [↓] \@array [↓] \%hash [↓] \&sub [↓]
Referințe: scalar anonim: $refscalar = \  [↓],[↓]
Referințe: array anonim: $refarray = [ ]  [↓],[↓],[↓]
Referințe: hash anonim: $refhash = { }  [↓],[↓],[↓]
Referințe: subrutină anonimă: $refsub = sub { }  [↓]
Referințe: exemple pentru niveluri multiple de referire [↓],[↓]
◦ Module: exemplu: [↓],[↓] modulul Chart [↓]
REGEX: Regular Expressions: [↓],[↓],[↓],[↓],[↓],[↓],[↓]
◦ OOP: Object-Oriented Programming: [↓],[↓],[↓]

Exemplele realizate la lucrările practice:
BMC:[↓] LM-A:[↓] LM-B:[↓] LM-C:[↓] GMO:[↓]
◦ Secvențe pentru exemple cu șiruri: [↓]
◦ Secvențe în format FASTA pentru exemple privitoare la citirea/scrierea fișierelor, de la Escherichia coli str. K-12 substr. MG1655, genele: [phoA] [sodA] [glnA] [cyaA] [fadA]

◦ Bibliografie [↓]

   

◦ Alternative Splicing Detection Tool, A novel PERL algorithm
for sensitive detection of splicing events [→]
◦ Bioinformatics and Medical Informatics:
Collaborations on the Road to Genomic Medicine? [→]
◦ Bioinformatics Explained (BioStars) [→]
◦ Bioinformatics Organization [→]
◦ Bioinformatics Resources [→]
◦ Bioinformatics Review Magazine [→]
◦ Bioinformatics: What the Clinical Laboratorian
Needs to Know and Prepare For [→]
◦ Clinical bioinformatics: A new emerging science [→]
◦ eliXir: Introduction to Perl: Programming for bioinformatics [→]
◦ EMBnet: The Global Bioinformatics Network [→]
◦ Genome Research Journal [→]
◦ Health Sciences Library System: Health Sciences
Communities at the University of Pittsburghy [→]
◦ Learn about Bioinformatics and Computational Tools for
Biology (Bioinformatics and Research Computing) [→]
◦ Geneva Foundation for Medical Education and Research:
Health informatics, bioinformatics, medical informatics [→]
◦ OBRC: Online Bioinformatics Resources Collection [→]
◦ Open Bioinformatics Foundation (OBF) [→]
◦ PLOS Computational Biology Journal [→]
◦ Protein Science: Special Issue:Tools for Protein Science [→]
RSBI: Romanian Society of Bioinformatics [→]
◦ The Bio-Web: Molecular and Cell Biology and Bioinformatics
news, tools, books, resources, web app. development [→]
◦ The Science Perl Journal [→]
◦ The Sequence Ontology Project [→]
◦ YourGenome: everything about DNA, genes and genomes [→]

PERL Resources   Biological Databases & Tools
 

◦ About Perl, Basics & Tutorials (ThoughtCo) [→]
ActiveState ActivePerl Free Community Edition [→]
◦ ActiveState Available Documentation [→]
◦ Alternative Splicing Detection Tool, A novel PERL
algorithm for sensitive detection of splicing events [→]
ASCII American Standard Code Information Interchange [→]
◦ Beginning Perl for Bioinformatics (book) [→]
BioPerl Project: open source Perl tools
for bioinformatics, genomics and life science
[→]
CPAN: Comprehensive Perl Archive Network [→]
◦ A Comprehensive Guide to Perl Programming
for Biologists (Omics Tutorials) [→]
◦ How Perl Saved the Human Genome Project [→]
◦ Learn Perl, CodesDope Courses [→]
◦ Learn Perl, Helping you get started with Perl [→]
List of computing and IT abbreviations [→]
◦ O'Reilly's CD Bookshelf (Perl ver.1 to ver.4) [→]
◦ Perl 5 by Example (by David Medinets) [→]
◦ Perl Beginners' Site [→]
◦ Perl for Biologists: Learning the basics of the Perl
programming through genomics examples [→]
◦ Perl Code for Performing an HTTP Request [→]
◦ Perl Hacks: Perl hacker's blog [→]
Perl Introduction and Tutorial from Tizag [→]
Perl Maven: Perl Tutorials and Courses [→]
Perl Maven RO: Traducere parțială în limba
română a tutorialului pentru începători
[→]
Perl Programming Documentation [→]
Perl Programming Language (GeeksForGeeks) [→]
Perl Special Variables [→]
◦ Perl Special Variables Quick Reference [→]
◦ Perl Tutorial for Beginners (BeginnersBook) [→]
◦ Perl Tutorial for Beginners: Learn in 1 Days [→]
Perl Tutorial with practical examples [→]
◦ Perl.com Quality articles about Perl programming [→]
Perl101.org: Provide you with everything that
every Perl programmer should know
[→]
◦ PerlMonks Tutorials [→]
◦ Practical Perl Programmingl [→]
RegEx: Complete Regular Expressions [→]
RegEx: Perl 5.32.1 Documentation [→]
RegEx101: Regular Expressions 101 [→]
◦ RegexOne, Learn Regular Exp. with simple ex. [→]
RegExr: tool to build & test Regular Expressions PCRE [→]
◦ Regular expressions in Perl tabular summary [→]
◦ RexEgg: world's most tyrannosaurical regex tutorials [→]
Strawberry Perl for Microsoft Windows [→]
◦ Ten Perl Myths (by Simon Cozens) [→]
The Perl Programming Language [→]
TutorialsPoint, Perl Programming Examples [→]
◦ Why use Perl in Bioinformatics? [→]

   

◦ ASD: Allosteric Database [→]
◦ BRENDA: Comprehensive Enzyme Information System [→]
◦ CIRCOS: Circular Visualization Software Package [→]
◦ DBAASP: Database of Antimicrobial Activity
and Structure of Peptides [→]
e!Ensembl: Genome browser & Perl API provides an
abstraction layer for accessing the genomic databases
[→]
◦ e!Ensembl: Train online provides a quick beginner's guide
to the overall structure of the Ensembl genome browser [→]
◦ e!EnsemblGenomes: for the annotation and interpretation,
comparative analysis and display genomes. [→]
EMBL-EBI: European Molecular Biology Laboratory
and European Bioinformatics Institute
[→]
◦ ExPASy: The SIB Bioinformatics Resource Portal [→]
◦ ExplorEnz: The Enzyme Database [→]
◦ FlyBase: A Database of Drosophila Genes & Genomes [→]
◦ Galaxy@Pasteur: A portal for bioinformatics analyses [→]
◦ GENCODE: Encyclopedia of genes and gene variants [→]
GenomeNet: Japanese network of database and
computational services for genome research and related
research areas in biomedical sciences. [→]
◦ GenomeTools: Genome analysis software [→]
GtP: Guide to PHARMACOLOGY [→]
HUGO: Gene Nomenclature Committee [→]
KEGG: Kyoto Encyclopedia of Genes and Genomes [→]
◦ MGI: Mouse Genome Informatics [→]
NCBI: Datasets, finding, browsing, and downloading data [→]
◦ NCBI: Genomes Download using FTP [→]
◦ NCBI: Human Genome Resources [→]
◦ NCBI: Genome Data Viewer. [→]
NCBI: National Center for Biotechnology Information [→]
◦ OMIM: Online Mendelian Inheritance in Mans [→]
◦ PROSITE: Documentation entries describing protein
domains, families and functional sites [→]
◦ REBASE: The Restriction Enzyme Database [→]
◦ RGD: Rat Genome Database [→]
SIB: Swiss Institute of Bioinformatics [→]
◦ SWISS-MODEL: a fully automated protein structure
homology-modeling server [→]
◦ TAIR: The Arabidopsis Information Resource [→]
◦ TCDB: Transporter Classification DataBase [→]
◦ TranscriptomeBrowser and InteractomeBrowser [→]
◦ UCSC Genomics Institute: Genome Browser [→]
◦ UniProt: Universal Protein Resource [→]
◦ Vega Genome Browser [→]
wwPDB: The Worldwide Protein Data Bank Archive [→]
◦ ZFIN: Zebrafish Model Organism Database [→]

Notepad++, IDE for PERL   Assemblies & Annotations for genes and genomes
 
◦ Notepad++ -> official site for download [→]
◦ Notepad++ -> program configuration as IDE for PERL
using NppExec through Plugin manager [→]
◦ Notepad++ -> Integrated Perl Debugging [→]
   

◦ European Nucleotide Archive: Features & Qualifiers [→]
◦ FASTA File Format for representing either
nucleotide or amino acid (protein) sequences [→] [→]
GDDBJ / ENA / GenBank Feature Table Definition [→] [→]
◦ GFF / GFF3: Generic Feature Format [→]
◦ GTF Gene Transfer Format description [→]
◦ NCBI: Annotating Genomes with GFF3 or GTF files [→]
◦ NCBI: Annotation Guide for Eukaryotic Genome [→]
◦ NCBI: Annotation Guide for Prokaryotic Genome [→]
◦ NCBI: Reference Sequence (RefSeq) [→]

     
       

 

Șef. lucr. dr. Călin Maniu
cmaniu@staff.uaic.ro